CURCUGENIX

Curcumin | Interview | Label

Known Benefits of Curcumin

Painful Inflammation
Stiffness of the Joints
Inflammation of Tendons
Autoimmune Conditions

 

Additional Benefits

Healthy Cholesterol
Anti-Oxidant Enzyme Profile
Pain reduction
Functionality in Elderly
Increase Nitric Oxide
Cognition

CurcuGenix Revolutionizes Curcumin

More Curcumin Potency into Each Capsule

CurcuGenix Revolutionizes Bioavailability

Experience the Power of Curcumin delivered by Protein Scaffold

CurcuGenix Revolutionizes Rapid Absorption

Complexes Whey Protein Isolate

The biggest obstacle to achieving optimum results from curcumin is getting adequate absorption. Curcumin is a crystalline shaped phytochemical when it’s isolated and extracted into its purest form. This makes it difficult to absorb in water and subsequently, challenging its ability to be absorb in the blood.

Recent advancements in nutritional science to get around these challenges have been the creation of various delivery methods such as Nano-curcumin, Liposomal curcumin, turmeric mixed with Piperine, and other branded versions. While these have all led to slightly more efficient turmeric supplements, it still has not reached levels that CurcuGenix has been able to achieve by using a patented protein bonding technology.

CurcuGenix has been able to take curcumin science to a whole new level. CurcuGenix uses a patent pending protein scaffold technology that drives curcumin absorption with the protein assimilation. It is a scientific fact that whey protein is the fastest absorbing protein known. Our studies have shown levels that are 185X assimilation over regular curcumin and 5 to 8X higher than nano-particle formulations. In fact with CurcuGenix most people report results in less than 2 hours. That’s right – tangible results in less than two hours. NO CLUMPING!

CurcuGenix starts with liquid curcumin. The protein scaffold then allows molecular curcumin to be delivered to the body because the curcumin preferential binds to protein before it will bind to itself.

Each Capsule of CurcuGenix contains 600 mg of Protein-Curcumin Complex. We use a fully balanced Curcuma Longa extract that is 95% pure complexed to a Whey Protein Isolate. Fast Absorbing CurcuGenix is complexed to whey protein (This is our Scaffolding Technology), which is scientifically proven to absorb within 20 minutes. This means you won’t be waiting for your Curcumin to absorb. Most people report results in less than 2 hours. We test every batch for heavy metals and microbes.

Curcumin

CURCUMIN IS A MIXTURE OF EXTRACTS DERIVED FROM TURMERIC.
Curcumin comes from Turmeric. About 3% of Turmeric is Curcumin. 

Curcumin is the biologically active polyphenolic compound found in turmeric, a spice derived from the rhizomes of the plant Curcuma longa linn. Turmeric is one of the world’s best-selling spices. Almost everyone has heard of turmeric and what it can do for the body. Turmeric gets most of the attention but it is the chemical component curcumin in turmeric that provides most of its benefits.

When the Curcumin is isolated, 3 Curcuminoid molecules are isolated:

Curcumin: About 75% of "curcumin" is Curcumin.
Demothoxy-Curcumin: About 17% of "curcumin is Demethoxy-Curcumin
Bisdemothoxy-Curcumin: About 3% of "curcumin is Bisdemethoxy-Curcumin

Most of the studies on this herb are using turmeric extracts that contain mostly curcumin itself, with dosages usually exceeding 1 gram per day. It would be very difficult to reach these levels just using the turmeric spice in your foods. If you want to experience the full effects, then you need to take an extract that contains significant amounts of curcumin. Since the curcumin content of turmeric is not that high…only around 3%, many people turn to supplementation with Curcumin as a way to receive therapeutic amounts.

While numerous benefits of curcumin have been discovered and studied we will focus on the anti-inflammatory properties. We encourage you to continue your own research on the other benefits curcumin has shown such as antioxidant activity, neuroprotective activity as well as its positive effects on cognitive decline, ulcerative colitis, oral health, type 2 diabetes and major depressive disorder.

This link provides a good place to start. Linus Pauling Institute at Oregon State University
http://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/curcumin

Curcumin & Anti-inflammatory Activity

Curcumin is a Natural Anti-Inflammatory Compound. Inflammation is an important function of the body because it helps the body combat foreign invaders and assists in repairing damage. Acute (short-term) inflammation is beneficial, yet it creates a major problem when it becomes chronic (long-term) and starts attacking the body’s own tissues.

Now it is understood, that chronic, low-level inflammation plays a major role in almost all chronic, Western diseases. Curcumin and other natural anti-inflammatory herbs that can help fight chronic inflammation is of potential importance in preventing and even treating these diseases.

It has been shown that curcumin is strongly anti-inflammatory, it is so effective that it matches the effectiveness of some anti-inflammatory pharmaceuticals.
Curcumin is effective because it targets multiple inflammatory pathways at the molecular level. Curcumin suppresses activity of at least 5 categories of molecular signals that promote inflammation and joint destruction in rheumatoid arthritis. One such factor is that Curcumin blocks NF-kB, a molecule that travels into the nuclei of cells and turns on genes related to inflammation. NF-kB is believed to play a major role in many chronic diseases.

Curcumin acts through multiple pathways and on numerous targets to limit the inflammatory response that underlies both rheumatoid and osteoarthritis. 
Understanding that curcumin is an excellent anti-inflammatory, it’s no leap to conclude that it may help with many arthritic conditions. Several studies validate this. In a study of patients with rheumatoid arthritis, curcumin was shown to be more effective than an anti-inflammatory drug. This is backed up by many other studies have looked at the effects of curcumin on arthritis with noted improvements several arthritic symptoms.

One study worth noting, was a three-month trial involving 50 patients diagnosed by with osteoarthritis of the knee. Half the participants took a turmeric formulation in addition to standard medical treatment; second group continued following their physicians’ initial treatments. 

The results were reviewed after 90 days. The researchers noted a 58 percent decline in overall reported pain and stiffness as well as an improvement in physical functioning among the turmeric group compared to the non-turmeric group. These changes were documented with a scoring method used to assess symptoms of knee and hip osteoarthritis. Another scoring method showed a 300 percent improvement in the emotional well-being of the turmeric patients compared non-turmeric group. Blood tests showed a 16X decline in C-reactive protein, an important bio-marker for inflammation. Patients in the turmeric group were able to reduce their use of non-steroidal anti-inflammatory drugs by 63 percent, in comparison to the non-turmeric group.   

This is obviously great news for the millions of people who suffer from osteoarthritis and have not received positive results from standard treatments.

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Interview

Fall 2016 Health Quarterly Interview with Adam Payne
Inventor and Formulator of CurcuGenix

Adam’s company has been able to take curcumin science to a whole new level in the last year. His curcumin supplement --can achieve peak curcumin levels in 20-40 minutes in the blood. His product is up to 14,000 times the bioavailability of standard Curcumin and ten times the bioavailability of phytosome preparations. 

Health Quarterly had the opportunity to interview Adam Payne about this new form of curcumin delivery. Below is a transcript of that interview. 

HQ:  Adam, thanks for your time. Tell our audience a little bit about your background and how you got into the curcumin business. 
Adam: Well, I was born a hippie, and I became a pharma; I did the reverse rebellion. I rebelled against my hippie roots and went into the Pharmaceutical industry and then while we were developing some fascinating things in rheumatology we came across some natural product extracts that were changing people’s lives over in India. 

That started me on a journey where I was kicking and screaming coming back into looking at natural medicine, natural substances such as a paradigm for how you could improve people’s health. It was in the context of developing a business around a natural extract for the treatment of eczema and psoriasis that we started a collaboration with some researchers that were looking at this very question we are talking about, which was the bioavailability of curcumin.

There were some researchers at the University of Oklahoma Medical Research Foundation named Dr. Hal Scofield and Dr. Biji Kurien who had spent a lifetime looking at ways of improving the kinetics of curcumin absorption. Their ideas were simple. They thought if we turn curcumin into a liquid we could get it into the body which makes sense because curcumin by itself if you look at it under a microscope is like quartz crystal. It’s insoluble in water and barely soluble in ethanol. It just doesn’t absorb like taking a bunch of rock crystals and saying I am getting raw minerals in my body. 

There is so little curcumin in turmeric that just taking raw turmeric does not allow for the transfer of the curcumin into the body. We initially approached it with these researchers to be a liquid. That gave birth to the patented technology that we brought out to the market just a little over a year and a half ago in 2014 called CurcuGenix.

HQ: Could you share with us what you were doing with the pharmaceutical company? I don’t want to dive too much into that. I just find it interesting that your background was pharmaceutical products and you left that industry for this. We don’t see too many people come from that sector and go into the natural.  
Adam:  You know you follow where your heart leads you to. I got into pharma work because it was designed to help people and one of the first companies I worked with was a cationic anti-microbial peptide designed to kill gram negative bacteria. That is a huge need and that product is still in development and will have a huge impact on human health. Another product I worked on as the CEO of the company was a combination therapy for inflammatory bowel disease. We had a combination therapy as both an enema and capsule that would deliver topically to the affected tissues in the colon and small intestine, and a combination therapy that we thought was going to have an enormous impact on IBD and Crohn’s disease. 

It’s one of those stories we threw millions of dollars at and the whole idea failed at clinical trial. It is one of the things that kind of bugged me about the pharma approach. We spent literarily close to 12 million dollars just to get it to that point, just to put it into a human study and test whether it worked. It turns out it didn’t do anything. 

One of the really cool things about what attracted me to what we are doing with nutritional supplements and natural medicine is that we can literarily go straight to testing this material on people right from the get-go. That’s what we did with our curcumin. 

Let me take a couple of steps back and explain what we did. Since we were looking at liquid curcumin, we started not from a solid like what is done when you make a Nano particle curcumin or micronize it, or encapsulate it in a liposome, micelle or phytosome. We started with a liquid, and we learned that the liquid had some fascinating interaction with proteins and other materials. The idea that we had was just really simple. Because of my Pharma experience we were always thinking about ways to deliver things into the body. We used the same concepts I learned in pharmaceuticals here. We knew how curcumin behaved with certain protein structures and I thought, well, we could just bind this curcumin to this protein scaffold potentially, coat the protein with this molecular monolayer of curcumin, and as the body is digesting the protein our thought was the body should just readily absorb the curcumin in the same molecular form. And lo and behold it did. 

We saw plasma levels in people when we measure it with chromatographic instrumentation that had never been seen before. Our first experiments were showing people getting over 2000 nanograms per ml of blood with a couple of capsules, and that was just unheard of. 

The clinical responses we were getting were just phenomenal. Obviously, we are not selling a drug we are selling a nutritional supplement, so we are not selling this as a treatment or as a cure for any disease, but as a way to help people improve their immune system. We are not selling it as a liquid. We use the liquid and bond it to whey protein and encapsulate it. Most people taking it just for inflammatory support are taking one capsule twice a day. For people that are looking for more that are dealing with inflammation that is out of control they are taking two capsules twice a day. Most people are getting more than adequate benefit out of that dosage.

HQ: When you say that curcumin is like crystal, that’s interesting to me because it is coming out of a plant source. Why is it in that type of shape or molecular form? 
Adam:  Curcumin is a highly prolific molecule; it binds to itself very quickly, so curcumin is extracted out of turmeric when you do the extraction, and most of the extractions that are done for getting curcumin out of turmeric are solvent extraction. It comes out, and they crystallize it down into a purified alkaloid material. When it gets into this purified stage, it turns into this crystal structure. 

HQ: So you are the first company in the USA that has done this particular process? 
Adam:  Yes, it is our intellectual property. There is a company taking the international patent that we are doing and trying to develop some drug strategies with it. I decided earlier on that we will see so much benefit out of this product that it will be immoral for me not to get it out into the marketplace as soon as possible.

HQ: Where do you obtain the Turmeric from that you use to extract the curcumin? 
Adam:  The turmeric is imported from an industry leading raw material supplier with connections to farmers across the world.  It is processed here in the U.S. We do our entire process here. All of our whey protein that we are using for the scaffold extract is mainly from Wisconsin cattle. All of our chemistry and ingredients that we buy are essentially made here in the U.S., so the extraction for the curcumin is done here, the whey protein is here, and we do all of our manufacturing to make the CurcuGenix complex here in our facilities. We are not outsourcing any of that. We control all the quality. 

HQ: So let’s get into the whole comparison of this particular version vs some of the other products that are in the market. There is the Nano Curcumin which you mentioned. There is the turmeric with piperine, the BCM-95.  Tell me what the different versions are and do a comparison. 
Adam: There are some great technologies out there and there are some technologies that aren’t that great. So let me start with the ones that are doing a great job. There is the BCM-95 technology which is curcumin plus turmeric oil.  That’s not a delivery system. It is getting into the body and people are seeing results in a couple of days, if not a couple of weeks. There is a loading that happens. We see levels of up to 40-50 nanograms per ml in the blood with a couple of capsules, so you are getting some serum exposure with BCM-95. Then we have the Nano Curcumin, the phytosomes, and the liposomal formulations. Those also are doing really well.  I think those are one step above the BCM95 product, although I think the BCM-95 people would probably take issue with that. But essentially there are really exotic methods for making micronized or nanoparticle sizes of curcumin and encapsulating them in different structures that enable the body to absorb them. They are getting levels up to 50-200 nanograms per ml with a couple of capsules. I think the highest I have seen is in the mid 100’s. The black pepper is really interesting. Black pepper, contrary to what many people are saying, does not increase the amount of curcumin that is absorbed in the body. We thought that was what it was doing earlier on, thinking that the black pepper was inflaming maybe the mucosa and the gut and allowing for more transport. 

When we went into literature, we rally started to understand what black pepper was doing. What black pepper does is that it inhibits an enzyme in the liver called glucuronidase. Glucuronidase is responsible for the breakdown of curcumin in the body so as it is passing through the liver, glucuronidase chops up the curcumin and makes it ineffective. When you add black pepper to your body, your body will then slow down the metabolism of the curcumin that is being absorbed, and so you see an increase in the level of curcumin that you have in your body, but it’s not because you are increasing the absorption. It is because you are decreasing the rate at which it is metabolized. 

My caution with black pepper is that black pepper will also slow down the metabolism of other things that you are taking and it will slow down more than 40 pharmaceutical products that people might be taking, and it could result in a dangerous situation for people that are taking drugs, not recreational drugs, but pharmaceutical drugs. It could increase the levels of these different drugs in the body. By in large, piperine is a safe material to take, but I would suggest that if anybody is taking a pharmaceutical product that they talk to their doctor to make sure piperine is not going to adversely affect the levels of that drug in their body. 

Piperine curcumin products will increase the bioavailability by a factor of 7, so if you take 2 grams of curcumin a day with piperine, you will see a blood signature of about 50 nanograms.  That is equivalent to having like 3-4 capsules of just pure curcumin plus piperine, but most people aren’t selling it that way. 
When you compare those strategies to what we have, there is a significant difference. We are seeing on average based on the data that we have today; one capsule is about 600 nanograms of curcumin into the body at peak levels. When you compare that to my competitors, it is a factor of about 140 more on a capsule to capsule comparison than just regular curcumin. It’s about 2030 times more than curcumin with black pepper extract, and it’s about a factor of 5-10 times more than the liposome and the nanoparticle products out there. That’s significant. 

Our absorption rate is really fast. On an empty stomach, we will see maximal exposure between twenty to forty minutes. How does that translate? It’s like you are getting this huge bolus of curcumin into your body in a very short period and the earlier obviously you get the curcumin into your body, the more beneficial it is going to be. Most of the other formulations take up to two hours to see a maximum level of distribution of their curcumin into the circulation. 

HQ: So how are you determining these blood measurements? 
Adam: We do it using a state of the art mass spec and liquid chromatography. If we extract blood from people at different points in time so we measure the levels of actual curcumin in the body using mass spec instrumentation it is pretty exact. The people that we measure are a lot of times me and some other co-workers. We have become human pin cushions, and that’s the price we pay for coming up with something. We do literarily pour or blood and sweat into this thing. 

HQ:  Wouldn’t it make sense based on what you are discovering that if you are not going to take a product such as yours that you would at least take curcumin or turmeric with whey protein or a protein supplement? 
Adam: That wouldn’t do it. It won’t do it because you have to go through the chemistry of binding the liquid curcumin to the protein sub strain, and there are some tricks to how you go about doing that, and that is done in chemistry. In optimal conditions, it takes a week to develop the chemistry. Our product isn’t that expensive; it’s up there, but for the benefits that most people are getting, most people find that the $40 to $50 they will be spending a month on the product are worth it. We haven’t had too many people complain. 

HQ: Is there anything else you would want to share with our audience about the product or what you guys are doing? 
Adam: Yes, there are some warnings that we’ve got. Curcumin does impact blood clotting kinetics through the thrombus pathway or the factor XA pathway. If anybody is taking blood thinners, especially Coumadin and warfarin, you should not ingest a curcumin product without consulting a qualified hematologist. The other warning that we have is that we don’t know whether curcumin will affect a developing fetus. Nobody has done studies at the level that we have to show whether curcumin will have an impact on a developing child in the mother’s womb. We will strongly suggest that anybody that is pregnant or thinking of getting pregnant not to take curcumin products until we have more data to support something like that. That’s just more of a precaution, but definitely, on the blood thinners, you want to stay away from curcumin until you have seen a hematologist. I will also caution that anybody that is on chemotherapy should talk to their oncologist and make sure they are aware of the effects the curcumin can have on their chemotherapy before taking it. I think that covers it. 

HQ: Ok, thank you for the interview. I appreciate your time.

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LABEL FACTS

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