Comprehensive Vitality Packages
Wellness Support for the 21st Century
Markit Health conducts comprehensive analyses of superior supplements and products that help create wellness. Thousands of hours of research and hundreds of interviews with doctors and scientists have prompted our company
to offer these exclusive comprehensive vitality packs for health and vibrant aging. These products are not available in any health store or vitamin shop but are used by hundreds of clinics and health care professionals across the United States and abroad.


Fibrin | Ingredients | FAQ | Label

CIRComplete Beneficial Effects:


• Cleaner Blood
• Fibrin Defense
• Joint Support
• Circulation Support
• Healing Support
• Less Pain


Acheive Healthy Circulation
with Normal Blood Viscosity

CIRComplete is a scientifically created blend of systemic enzymes with antioxidants specifically formulated to support healthy circulatory and immune function.*

The CIRComplete enzyme blend is vegetarian and has been tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† These systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream as opposed to the gastrointestinal tract.

CIRComplete supports healthy levels of EBP’s (Endogenous Blood Particles).* EBP’s are made up of decayed cells, fibrin, fatty proteins, and other unwanted materials that normally build up in the blood.*

The systemic enzymes that are found in CIRComplete support the natural purification of EBP’s. These systemic enzymes also assist in maintaining healthy liver function and healthy inflammatory levels.

Maintaining proper levels of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* CIRComplete contains a proven potency that can be utilized by consumers and healthcare professionals alike. CIRComplete contains enzymes that are significantly different from typical systemic enzymes derived animal sources. The enzymes in CIRComplete are a combination of vegetarian and selectively potent microbial strains. These ingredients are extremely effective and are well tolerated in the body.

Clinical research performed on CIRComplete and other recent medical breakthroughs have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* These systemic enzymes support a reduced level of EBP’s. Healthy, reduced-EBP blood helps to sustain normal blood clotting factors.

Systemic enzymes also support a healthy immune system and may support the repair damaged tissues, and they can require smaller doses over time to maintain their efficacy.* Systemic enzymes can support healthy inflammatory responses and their relation to joint discomfort and stiffness.*

Anyone over 40 can greatly benefit from this product. CIRComplete is a combination of enzymes that helps break down toxins in the cardiovascular system. Removing toxins from the blood will reduce the likelihood of abnormal clotting while improving circulation. Anytime you can improve circulation you will help alleviate inflammation. CIRComplete is commonly used to break down fibrin.

Not all enzyme blends are created equal. There are a handful of enzyme formulations that actually work. The formulators of CIRComplete have created some of the best enzyme products available. Enzyme potency is measured by activity levels. When enzymes are added to liquid they become active. Simply adding more milligrams (mg) of enzymes does not necessarily make the product stronger. Activity levels are measured by “FUs” or fibrinolytic units. With most enzyme blends, typical serving size is one to two capsules, providing an average of 1,000 to 2,000 FUs. CIRComplete provides 15,000 FUs per serving, yielding 133 percent higher activity levels. When choosing an enzyme look carefully for FUs rather than simply mg per serving.

†Based on 3rd party fibrinolytic assay testing. 

Fibrin Defense

Fibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. CIRComplete contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in CIRComplete.

Fibrinogen Over-Production
Hyper-coagulation & Fibrin Defense
Enzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. CIRComplete contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as CIRComplete – Fibrin Defense. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself.

Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing.

As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8].

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CIRComplete is a proprietary combination of systemic enzymes including serrapeptase, nattokinase, bromelain, papain, and lipase.

CIRComplete’s 2 Main Components 
NattoSEB® Recently a new enzyme with potent fibrinolytic activity that rivals pharmaceutical agents has been discovered and shows great potential in providing support for hypercoagulative states. This all-natural enzyme, NattoSEB (Nattokinase), is derived from the bacteria Bacillus Natto. Already, backed by research, NattoSEB (Nattokinase) shows promise in supporting areas such as cardiovascular disease, stroke, angina, venous stasis, thrombosis, emboli, atherosclerosis, fibromyalgia/chronic fatigue, claudication, retinal pathology, hemorrhoid, varicose veins, soft tissue rheumatisms, muscle spasm, poor healing, chronic inflammation and pain, peripheral vascular disease, hypertension, tissue oxygen deprivation, infertility, and other gynecology conditions (e.g. endometriosis, uterine fibroids). Several human clinical trials have been conducted on the effectiveness of NattSEB.  Please request a copy of these trials from your distributor.

Peptizyme® SP Peptizyme SP, also known as Serratiopeptidase, is a proteolytic enzyme isolated from the nonpathogenic enterobacteria Serratia sp. T-1. When consumed in unprotected tablets or capsules, the enzyme is destroyed by acid in the stomach. However, enterically-coated tablets enable the enzyme to pass through the stomach unchanged, and be absorbed in the intestine.  Clinical studies show that Peptizyme SP induces fibrinolytic, anti-inflammatory and anti-edemic (prevents swelling and fluid retention) activity in a number of tissues, and that its anti-inflammatory effects are superior to other proteolytic enzymes.  Besides reducing inflammation, one of Peptizyme SP's most profound benefits is reduction of pain, due to its ability to block the release of pain-inducing amines from inflamed tissues. Physicians throughout Europe and Asia have recognized the anti-inflammatory and pain-blocking benefits of this naturally occurring substance and are using it in treatment as an alternative to salicylates, ibuprofen and other NSAIDs.



A fibrinolytic enzyme derived from the fermentation of Bacillus subtilis that can help to maintain normal blood viscosity and normal cardiovascular health.


A proteolytic (protein digesting) enzyme with potent fibrinolytic activity can support healthy fibrin concentrations. It has been clinically shown to support healthy mucus viscosity and promote normal recovery after physical stress.


Used systemically, this enzyme digests fats in the blood and can help convert fats into fatty acids, which may be expressed or retained as energy.


A proteolytic enzyme that, when present in blood serum, plays an important role in the blood’s health. It can also help support a healthy immune system and improve circulatory health.


Derived from Indian Gooseberry, amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain pH balance, and has a high concentration of naturally derived vitamin C.


A proteolytic enzyme derived from papaya that can promote normal healing and inflammation from overexertion.


A flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.


Decreases the proliferation of free radicals, supporting a healthy immune system. Co-Q10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.


Promotes a healthy cardiovascular system, and is essential for cell repair, hormones, and a regular heartbeat. Magnesium also helps reduce the effects of increased stress.

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What is CIRComplete?

CIRComplete is a proprietary combination of serrapeptase, nattokinase, protease, lipase, bromelain, papain, rutin, amla, and other proteolytic enzymes that are specially formulated to support healthy fibrin levels. CIRComplete has been used to support immune and circulatory health, as well as maintain a healthy inflammatory response to everyday activity.

What are enzymes?

Enzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital proteins, as they only react with certain harmful proteins in the body.

What are systemic enzymes?

When enzymes are introduced into the bloodstream, they work systemically, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the small intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as serrapeptase and nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as fibrin.

What is fibrin?

Fibrin is a protein substance naturally formed in the human body. It plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation and is produced in reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions.

Why CIRComplete?

As we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation, and an overall balanced reaction to overexertion.

How does CIRComplete work?

By supplementing and replenishing the body's diminishing enzymes, CIRComplete provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels, thereby helping to maintain healthy fibrin levels.

Is CIRComplete enteric coated?

Enteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas?
We have instead developed an all-natural, chemical-free acid armor capsule. These capsules are comprised of an extra thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid armor capsules have been designed to delay the release of the capsule's contents for up to an hour, without the use of potentially harmful chemicals.

Is CIRComplete safe?

Yes. There have been no reports of any serious or adverse side effects from taking systemic enzymes such as CIRComplete. If you are taking a prescription blood-thinning medication (not including daily aspirin), you should consult with your physician before taking CIRComplete.

When is the best time to take CIRComplete?

For best results, take the product at least one hour prior to eating and/or two hours after a meal.

Can I take CIRComplete with other supplements?

CIRComplete can be used safely with other dietary supplements.

How long does it take for CIRComplete to work?

Although every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of one month's time is recommended, with the best results occurring anywhere from one to three months thereafter.

Is CIRComplete Kosher?

The formula is Kosher, and a copy of the certification is available by request.

Is CIRComplete vegetarian?

The CIRComplete formula is vegetarian in accordance with the guidelines of the American Vegetarian Association.

Is CIRComplete non-GMO (Genetically Modified Organism)?

Yes, CIRComplete is non-GMO. The microorganisms used to produce this enzyme product are not genetically engineered organisms as defined by the National Organic Standards Board. Genetically engineered is defined as follows: Made with techniques that alter the molecular or cellular biology of an organism by means that are not possible under natural conditions or processes. Genetic engineering includes recombinant DNA, cell fusion, micro-and macro-encapsulation, gene deletion and doubling, introducing a foreign gene, and changing the position of genes. It shall not include breeding, conjugation, fermentation, hybridization, in-vitro fertilization, and tissue culture.




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These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any pharmaceutical product without first consulting your prescribing physician. Resale of Markit Health, LLC products without written permission is strictly prohibited. Prices Are Subject to Change. Updated 3/20/19.